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Abstract #2280

Prenatal Maternal Depression and Anxiety Alter Hippocampal Development in Fetuses

Yao Wu1, Diane Lanham, Samantha Bauer, Gilbert Vezina, and Catherine Limperopoulos

1The Developing Brain Research Laboratory, Children’s National Health System, Washington, DC, United States

The hippocampus plays an important role in stress regulation. This study aims to investigate the relationship between prenatal maternal stress and fetal hippocampal volumetric growth using magnetic resonance imaging (MRI). Results suggest that maternal depression and anxiety are associated with smaller left hippocampal volumes in female fetuses in the third trimester of pregnancy.

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