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Abstract #2281

A pilot study of lateral ventricle volume from in utero foetal brain magnetic resonance imaging (MRI)

Dadi Zhao1,2, Dantong Miao3,4, Rui Shen2, Feng Wang5, Bing Zhu4, Yu Sun5,6, and Bing Zhang4

1State Key Laboratory of Bioelectronics, Southeast University, Nanjing, People's Republic of China, 2School of Biological Science and Medical Engineering, Southeast University, Nanjing, People's Republic of China, 3The First School of Clinical Medicine, Nanjing Medical University, Nanjing, People's Republic of China, 4Department of Radiology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China, 5Southeast University - Jiangsu Institute of Biomaterials and Medical Devices, Nanjing, People's Republic of China, 6Institute of Cancer and Genomic Science, University of Birmingham, United Kingdom

Neuroimaging for foetus brain is a challenging problem in which there are several issues to be solved. We proposed a general solution and finally reconstruct the lateral ventricle volume that is of great significance for clinical study. Firstly, slices were realigned to correct for the motion between acquisition of individual slices including transposition and rotation. Secondly, slices with motion artefacts were excluded and inconsistencies in intensity patterns resulting from the motion were estimated and corrected for. Thirdly, the structure of lateral ventricle was segmented via adaptive segmentation. Finally, the volume was reconstructed from irregularly sampled data.

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