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Abstract #2287

Lipid fractions as a marker for myelin maturation in the developing brain

Benyamin Deldar1, Emer Hughes1, Nora Tusor1, Serena Counsell1, A. David Edwards1, and J-Donald Tournier1

1Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Myelination is an important aspect of brain development, but current myelin mapping techniques require extensive acquisition times and are therefore difficult to use routinely in neonates. In this study, we present results from a large cohort of neonates born preterm spanning a wide age range (26 to 125 weeks’ post-menstrual age) obtained using a recently proposed method that relies on existing routine data. Our results show good agreement with the expected spatial and temporal pattern of myelin formation over the age range studied, and may form the basis for future studies assessing myelin in the developing brain.

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