Abstract #2296

White Matter Abnormalities in Congenital Heart Disease Assessed Using Advanced Diffusion Imaging

Sarina Karmacharya¹, Borjan Gagoski², Lipeng Ning¹, Martha E. Shenton^1,3, Ellen Grant², and Yogesh Rathi¹

¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ²Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ³VA Healthcare, Boston, MA, United States

The study examined white matter (WM) abnormalities in neonates with Congenital Heart Disease (CHD) (19 CHD and 16 typically developing (TD) neonates). Gaussian mixture model showed that neonates with CHD have lower cellular volume and density in UF, SFOF, left IFOF, and CC. Fractional Anisotropy was lower in neonates with CHD in bilateral UF, CC, and left SLF. NODDI results indicated lower intracellular volume in the bilateral SFOF, and higher fiber orientation dispersion in the left CC and SLF in CHD. Our results demonstrate that significant WM abnormalities related to language areas are seen in neonates with CHD.

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