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Abstract #2297

BOLD MR Imaging of Placenta in Congenital Heart Disease

Vincent Kyu Lee1,2, Alexander M. El-Ali3, Alexandria Zahner2, Kavita Vani4, Vidya Rajagopalan5, Michelle Gruss2, Jennifer Adibi6, Vincent J. Schmithorst1,2, and Ashok Panigrahy1,2

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 3Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 4Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 5Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, 6Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States

We examined whether features of placental BOLD MRI in underlying setting of fetal congenital heart disease (CHD) differ from those of healthy controls, and the imaging data correlated with first trimester maternal serum markers (PAPP-A, β-hCG) known to influence vasculogenesis/angiogenesis. We explored correlation between fetal brain resting stat networks and imaging and hormonal biomarkers of the placenta. We used temporal, spatial, and spatio-temporal to analyze the squared-root-mean variance and distribution differences in BOLD signal between CHD and controls. Difference in spatial and temporal BOLD signal variance is present in CHD pregnancies compared to healthy controls were observed.

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Abstract