We examined whether features of placental BOLD MRI in underlying setting of fetal congenital heart disease (CHD) differ from those of healthy controls, and the imaging data correlated with first trimester maternal serum markers (PAPP-A, β-hCG) known to influence vasculogenesis/angiogenesis. We explored correlation between fetal brain resting stat networks and imaging and hormonal biomarkers of the placenta. We used temporal, spatial, and spatio-temporal to analyze the squared-root-mean variance and distribution differences in BOLD signal between CHD and controls. Difference in spatial and temporal BOLD signal variance is present in CHD pregnancies compared to healthy controls were observed.
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