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Abstract #2298

Multi-shell Multi-band Diffusion Imaging (MSMBDI) is more predictive of executive deficits in Preadolescents with Complex Congenital Heart Disease (CHD) compared to standard diffusion tensor imaging (DTI)

Vincent Kyu Lee1,2, Mark Greenhalgh1,2, William T. Reynolds1,2, Timothy D. Verstynen3, Fang-Cheng Yeh4, Cecilia W. Lo5, Vincent J. Schmithorst1,2, and Ashok Panigrahy1,2

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 3Psychology, Carnegie Mellon University, Pittsburgh, PA, United States, 4Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States, 5Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States

We tested whether Multi-shell Multi-band Diffusion Imaging (MSMBDI) would be superior to standard DTI at delineating microstructural cortical association fiber abnormalities and predicting executive function preadolescents with complex congenital heart disease (CHD). Using both a hypothesis-driven approach (manual tractography) and a data-driven approach (q-space diffeomorphic reconstruction) we examined white matter tracts in correlation with NIH Toolbox and complementary battery of neuropsychological test. We show that MSMBDI – when compared to standard DTI – showed greater sensitivity towards white matter structure differences, superior at detecting microstructural differences in cortical association tracts in CHD compared to controls, and more predictive of executive deficits.

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