The study assessed the effects of (DRD4) -616 (rs747302) gene variation on gray matter volume (GMV) and arousal from sleep (AS) scores in children that suffered from primary nocturnal enuresis (PNE) and normal controls and found that The −616 C/G SNP in the DRD4 promoter may affect the AS scores and GMV in the thalamus and pregenual ACC in PNE children.
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