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Abstract #2302

Altered regional brain activities in children with nonsyndromic cleft lip and/or palate (CL/P): a resting-state functional MRI study

Hua CHENG1, YingZi GAO1, Yang FAN2, WenJing ZHANG3, and Yun PENG1

1Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, 2MR Research China,GE Healthcare, 3Beijing Stomatological Hospital, Capital Medical University

Resting state-fMRI has been widely used as an effective method to evaluate the of brain functional changes in physiological and pathological process. Altered regional brain activities, especially in verbal and cognitive areas were found in children with nonsyndromic CL/P using resting-state fMRI. It helps to understand the abnormality of functional architecture of CL/P which implies different structures and cognitive patterns in CL/P compared with normal development children.

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