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Abstract #2304

Microstructural heterogeneity of Superior longitudinal fasciculus (SLF-II) predicts impulsivity in healthy young girls

Yogesh Rathi1, Julia Cohen-Gilbert1, Michael Rohan1, Elizabeth Olson1, Benjamin Reid2, Sarina Karmacharya2, Martha E Shenton1, Sion Harris1, and Marisa M Silveri1

1Harvard Medical School, Boston, MA, United States, 2Brigham and Women's Hospital, Boston, MA, United States

Diffusion MRI (dMRI) is sensitive to microstructural arrangement of cells and axons in the brain. In this abstract, we analyzed dMRI data from 30 healthy children (14 girls, 13.9 ± 0.8 yrs, 16 boys, 13.4 ± 0.9 yrs). Advanced multi-tensor tractography was used to trace the SLF-II and heterogeneity in fractional anisotropy (HFA)4 (the standard deviation in FA) was computed in all subjects. Subjects were separated into two groups (males, females) and correlation between HFA and total Barratt Impulsivity Scores (BIS) was computed for each group. A statistically significant correlation was found between HFA in left SLF-II and BIS in girls but not in boys. The SLF-II has been known to be involved in spatial attention and executive control and higher heterogeneity in white matter integrity in SLF-II seems to be involved in impulsive/attentional network in young girls but not boys.

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