The aim of this study is to apply DTI-based
connectome analysis to investigate the neural substrate and mechanism of picture
exchange communication system (PECS) in young children with ASD. Seventeen
non-verbal children with ASD who underwent PECS and 3T DTI (age: 3.05±0.82 years, 10 boys) were retrospectively selected
for whole brain connectome analysis . Compared with 5 children who failed PECS (non-verbal after PECS), 12 children who succeeded PECS (verbal after PECS) showed significantly increased betweeness, local efficiency and nodal
strength in anterior inferior occipital gyrus (p <0.01). Such increases may
be an effective imaging marker to detect ASD children who will become verbal
after PECS.
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