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Abstract #2316

Quantitative evaluation of brain volume change after phthalate esters exposure using voxel-based morphometry

Ju-Chien Wu1, Jun-Cheng Weng1,2, Jeng-Dau Tasi3, Chao-Yu Shen1,2,4, and Shu-Li Wang5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 3School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan, 4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 5National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan

The products made by phthalate esters could be found everywhere. But there were only a few studies mentioned about the influence of phthalate esters exposure on brain volume. We used the voxel-based morphometry analysis to observe the correlation between the concentrations of maternal urine phthalate esters (MBP, MBzP, DEHP, MEHP, MEOHP) and children’s brain volume of gray and white matter. We found the negative correlation between the concentrations and the volume of frontal gyrus and cingulate gyrus.

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