Meeting Banner
Abstract #2321

brain iron accumulation in amyotrophic lateral sclerosis -  a quantitative susceptibility mapping study

Qiuli Zhang1, Haining Li1, Yuchen Zhang1, Dandan Zheng2, Lijun Bai3, and Ming Zhang1

1Radiology, the First Affilicated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China, 2GE Healthcare, MR Research China, Beijing, People's Republic of China, 3School of Life Science and Technology, Xi'an Jiaontong University, the Key Laboratory of Biomedical Information Engeering, Ministry of Education, Xi'an, Shaanxi, People's Republic of China

Iron accumulation can induce a wide range of neuron disorders in central nerve system. Increased serum ferritin has been found to predict poor clinical outcome in ALS. We used quantitative susceptibility mapping to explore brain iron accumulation and theri clinical relevance. Increased iron level has been found in both cortical and subcortical motor related regions. The iron concentration in the primary motor cortex is responsible for deteriorated clinical syndrome, suggested its potential role for disease management. While increased iron concentration in the bilteral caudate contributed to impaired executive function, indicated network-based dysfunction for cognition decline in ALS.

This abstract and the presentation materials are available to members only; a login is required.

Join Here