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Abstract #2320

Mapping brain functional alterations in chemotherapy-treated breast cancer women using resting-state fMRI

Xuan-Ru Zhang1, Vincent Chin-Hung Chen2,3, Dah-Cherng Yeh4, Chao-Yu Shen1,5,6, and Jun-Cheng Weng1,6

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2School of Medicine, Chang Gung University, Taoyuan, Taiwan, 3Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 4Breast Center, Taichung Tzu Chi Hospital, Taichung, Taiwan, 5Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 6Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Breast cancer (BC) is one of the common public health problems, and chemotherapy was the major treatment for breast cancer. The previous study showed abnormal brain function was associated with the late effects of chemotherapy (5 to 10 years). The purpose of our study was to evaluate the early effects of post-chemotherapy BC patients (in 6 months). We investigated the resting-state functional differences between post-chemotherapy BC patients and healthy control. Our results provided the evidence of brain functional changes in women with breast cancer and highlight the importance of the breast cancer-related chemotherapy.

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