Abstract #2319

Brain structural MRI and perfusion signature of ALS patients with different levels of cognitive deficits

Bo Hou¹, Dong-chao Shen², Pan Peng², Bo Cui², Xiao-lu Li¹, Hui You¹, Li-zhi Xie³, Li-ying Cui², and Feng Feng¹

¹Radiology, Peking Union Medical College Hospital, Beijing, People's Republic of China, ²Neurology, Peking Union Medical College Hospital, Beijing, People's Republic of China, ³Ge Healthcare, MR Research China, Beijing, People's Republic of China

This study was done to explore potential brain changes in ALS patients with different levels of cognitive deficits with voxel-based analysis of CBF generated by pCASL and VBM. Significant GM loss and CBF decrease were demonstrated in the severe frontotemporal dementia group. No difference of GM or CBF was found between ALS-Cn and ALS-Ci. Differences between ALS-Ci and ALS-FTD overlapped with those found between ALS-Cn and ALS-FTD, and the changes were more widespread in the latter contrast.

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