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Abstract #2318

No Evidence of Increased Iron Accumulation in the Deep Gray Matter of Patients with Amyotrophic Lateral Sclerosis (ALS)

Florian Borsodi1, Valeriu Culea1, Christian Langkammer1, Michael Khalil1, Lukas Pirpamer1, Stefan Quasthoff1, Christian Enzinger1,2, Franz Fazekas1, and Stefan Ropele1

1Department of Neurology, Medical University of Graz, Graz, Austria, 2Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria

Iron accumulation in deep gray matter occurs during normal aging, but has also been observed in several neurodegenerative diseases. To investigate if this still holds true for ALS, we aimed at assessing the iron content in deep gray matter structures of 24 ALS patients with quantitative susceptibility mapping and its relation to 28 controls. We did not find any significant differences in iron levels between ALS patients and controls. This may indicate that iron accumulation in deep gray matter is a specific feature that is not associated with neurodegenerative diseases in general, but rather reflects more specific degenerative processes.

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