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Abstract #2323

Investigation of neuroinflammation and cognitive dysfunction following a major burn injury and critical care admission using advanced MR imaging

Mary Elizabeth Finnegan1,2, Matthew Grech-Sollars1,3, Lesley Honeyfield1,3, Philip Benjamin1, Rebecca Quest1,3, Edward JR Watson4,5, Naz Nordin4,5, Olivia Clancy4,5, Ahmed Al-Hindawi4,5, Agnes Nilsen6, Ashley Mehmet6, Klara Nenadlova6, Lisa Williams4, Trudi Edginton6, Sara De Simoni3, Marcela Vizcaychipi4,5, and Adam Waldman3,7

1Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 2Department of Bioengineering, Imperial College London, London, United Kingdom, 3Department of Medicine, Imperial College London, London, United Kingdom, 4Magill Department of Anaesthesia, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom, 5Department of Academic Anaesthesia, Imperial College London, London, United Kingdom, 6Department of Psychology, Westminster University, London, United Kingdom, 7Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

We used advanced MR imaging methods to investigate neurophysiological changes following major burns injury in a cohort of patients with reduced cognitive function compared to age and sex-matched controls. In this preliminary study, small regions of increased connectivity were observed in patients in two brain networks extracted from resting-state fMRI data using ICA. However, the significance of these results is unclear given the broad range of neurological functions implicated by the cognitive deficits. Furthermore, we found no significant difference between patients and controls for TBSS, volumetric analysis and MR spectroscopy. SWI indicated large areas of microbleeds in one patient.

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