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Abstract #2324

Region-specific damage in Progressive Supranuclear Palsy studied using multimodal quantitative MRI

Nadya Pyatigorskaya1,2,3, Rahul Gaurav3, Claire Ewenczyk4, Cecile Gallea3, Romain Valabregue3, Fatma Gargouri3, Eric Bardinet3, Isabelle Arnulf2,5, Cyril Poupon6, Marie Vidailhet2,4, and Stephane Lehericy1,2,3

1Neuroradiology department, APHP, Pitié Salpêtrière, Paris, France, 2UPMC Univ Paris 06, UMR S 1127, CNRS UMR 7225, ICM, F-75013, Sorbonne Universités, Paris, France, 3Centre de NeuroImagerie de Recherche – CENIR, ICM, Paris, France, 4Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, APHP, Paris, France, 5Service des pathologies du Sommeil, Hôpital Pitié-Salpêtrière, APHP, Paris, France, 6NeuroSpin, CEA, Gif-Sur-Yvette, France

We used quantitative multimodal MRI to investigate the region-specific damage in progressive supranuclear palsy (PSP) in order to generate a precise model of neurodegeneration at various levels of the central nervous system, including brainstem nuclei, basal ganglia and cortex. PSP patients showed extensive volume decrease and microstructural diffusion changes in the brainstem and the basal ganglia in agreement with previous pathological studies. These results suggest the possibility of direct noninvasive assessment of brain damage in PSP not only in the basal ganglia and the cortex, as done previously, but also in small brainstem nuclei.

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