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Abstract #2326

Dynamic Quantitative Imaging of Sodium During Migraine Onset and Propagation at 21.1 T

Nastaren Abad1,2, Jens T. Rosenberg1, Samuel Colles Grant1,2, and Michael G. Harrington3

1Center for Interdiscplinary Magnetic Resonance, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 3Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States

The brain allocates >50% of its energy reserves to the regulation of sodium homeostasis, indicating the critical importance of sodium and its fluxes in normal brain and neurological disorders. The purpose of this study was to evaluate in vivo 23Na in the brain using a rat model of migraine induced by nitroglycerin injection. The ultra-high field of 21.1 T was employed to quantify alterations in bulk sodium during and following the onset of central sensitization related to migraine. Multi-slice 2D CSI of sodium were acquired longitudinally to identify localized increases in sodium concentrations during a 3-h period following sensitization induction.

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