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Abstract #2327

Endogenous assessment of hippocampus degeneration in end-stage renal disease with T1rho mapping and its comparison to voxel based measurement

Lin Wang1 and Shenghong Ju1

1Radiology, Zhongda hospital, Medical school of Southeast university, Nanjing, People's Republic of China

It is reported that the brain always be an injured target organ in end-stage renal disease (ESRD) patients, a series of pathophysiologic changes easily make the iron accumulate in brain and accelerate the brain degeneration, which results in the brain cognitive function decline. T1rho relaxation time can reflect the changes of the macromolecular substance content and can be shorten by the Paramagnetic component, which makes it the ability to distinguish the healthy controls from ESRD patients. Voxel based measurement as a classical methods to verify the volume of each brain section, which can be also used to represent the structure of the brain. Combined with the results of neuropsylogical tests, T1rho mapping can better characterize the hippocampus in ESRD patients and the conclusions give a support for considering that the brain function changes earlier than structure changes.

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