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Abstract #2332

Altered whole brain connectivity related to time of drug usage in methamphetamine abusers

Ming Zhou1, Xiaobo Zhou2, Xinyu Hu1, Lu Lu1, Lianqing Zhang1, Jing Li2, Jiayu Sun1, and Xiaoqi Huang1

1Department of Radiology, Huaxi MR Research Center, Chengdu, People's Republic of China, 2Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, People's Republic of China

The current study aimed to use a novel graph-theory approach known as degree centrality to help diagnose methamphetamine abusers. Our findings identified increased degree centrality in right middle frontal gyrus, right inferior frontal gyrus and anterior cingulate cortex and degree centrality reductions were revealed in right superior parietal lobe and bilateral lingual gyrus. Additionally, decreased degree centrality of right lingual gyrus negatively correlated with the duration of methamphetamine abuse. Meanwhile, decreased degree centrality of right lingual gyrus might be a predictor of methamphetamine abuse duration with an acceptable diagnostic accuracy of 71%.

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