Abstract #2331

Enhanced visualization of lesions in focal cortical dysplasia using the fluid and white-matter suppression (FLAWS) sequence

Xin Chen¹, Tianyi Qian², Tobias Kober^3,4,5, Nan Chen¹, and Kuncheng Li¹

¹Radiology, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China, ²MR Collaborations NE Asia, Siemens Healthcare, Beijing, People's Republic of China, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Radiology, University Hospital (CHUV), Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

High contrast in the lesion area is one of the most important prognostic factors for focal cortical dysplasia (FCD). The fluid and white-matter suppression (FLAWS) sequence provides two sets of 3D contrasts from one acquisition: one nulls the white-matter signal, the other nulls the cerebral spinal fluid signal. A new image (the FLAWS contrast) calculated from these two images may enhance the visualization of FCD lesion features, specifically the blurred grey-white matter interface and the transmantle sign. In this study, we assessed the ability of FLAWS to visualize FCD lesions. Our results demonstrate that FLAWS is sensitive to lesional tissue, especially the transmantle sign, providing additional value in MR-based FCD diagnostics.

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