The m.3242A>G mitochondrial mutation is known to cause the MELAS syndrome. A group of MELAS patients was scanned using multi-parameter quantitative 7T MRI to assess brain changes related to mutation load and disease duration. Here, we focused on cortical thickness differences between control subjects and MELAS patients and within patients as a function of mutation load. MELAS patients were characterized by a reduced cortical thickness compared to control subjects in several regions. Within these regions, cortical thickness decreases with increasing mutation load for the fusiform and planum temporal gyri, which are involved in visual working memory and auditory processing, respectively.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords