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Abstract #2338

Age-related change of the whole brain T1 relaxation time: voxel-wise study with MP2RAGE

Gosuke Okubo1, Tomohisa Okada1, Akira Yamamoto1, Yasutaka Fushimi1, Tsutomu Okada1, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Correlation was investigated between normal aging and T1 relaxation time in the deep gray matter with MP2RAGE sequence using voxel-based analysis (VBA) and regions-of-interest (ROIs) focusing on the deep gray matter (GM). Seventy healthy subjects were included. In VBA, linear correlation was explored, whereas second order regression was added in ROI analysis. The results showed relationship that varied among deep GM structures. Those findings will shed light on further investigation of T1 relaxation time in patient groups.

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