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Abstract #2339

Factors influencing the detection of age-dependent variations of cortical myelin by MP2RAGE at 9.4T.

Gisela E Hagberg1,2, Jonas Bause2, Thomas Ethofer1,3, Philipp Ehses2, Thomas Dresler1, Cornelia Herbert4, Rolf Pohmann2, gunamony Shajan2, Andreas Fallgatter1, Marina Pavlova1, and Klaus Scheffler1,2

1Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, 2High Field Magnetic Resonance, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany, 33General Psychiatry&Psychotherapy, University Hospital Tübingen, Tübingen, Germany, 4University Ulm, Germany

Detection of subtle variation of the myeloarchitecture within the cerebral cortex may be feasibile with high-field mapping of the longitudinal relaxation time. However, besides myelin other factors like iron or variation of the grey matter volume may impact this MR parameter. In the present work we propose a model that includes and quantifies these factors. We found a regionally dependent, continuous increase from early adulthood into the middle ages that tentatively can be assigned to myelin.

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