Abstract #2341

Neuromelanin-weighted MRI in revealing human development and age-related changes in locus coeruleus and substantial nigra

Yue Xing^1,2, Abdul Halim Sapuan¹, Robert Dineen^1,3, Andrew Cooper⁴, and Dorothee Auer⁴

¹1Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ³Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, United Kingdom, ⁴Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre;, University of Nottingham, Nottingham, United Kingdom

Rapid neuromelanin-weighted MR imaging sequence was performed to noninvasively inspect the physiological changes of substantial nigra and Locus ceruleus across a wide range of age in healthy subjects using neuromelanin-sensitive MRI for the first time.

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