Abstract #2342

Characterizing brain iron deposition in patients with subcortical vascular mild cognitive impairment using quantitative susceptibility mapping: A potential biomarker

Yawen Sun¹, Yan Zhou¹, Yao Wang¹, Xu Han¹, Weina Ding¹, Yong Zhang², Qun Xu³, and Jianrong Xu¹

¹Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China, ²Ge Applied Science Laboratory, GE Healthcare, Shanghai, People's Republic of China, ³Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China

The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) or their effects on cognition has rarely been investigated. The purposes of the present study were to investigate brain iron deposition in deep gray matter nuclei in svMCI patients using quantitative susceptibility mapping (QSM) and its correlation with the severity of cognitive impairment. Susceptibility values were found to be elevated within bilateral hippocampus and right putamen in svMCI group compared with controls, which were related to cognitive measurements. Our result suggests that brain iron deposition which relation to cognition indicates the clinical relevance of the biomarker.

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