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Abstract #2358

A Potential Biomarker of Alzheimer's Disease: T1sat of the Thalamus

Parshant Sehrawat1, H. Michael Gach2, Wenna Duan1, Andrea Gillman3, James T. Becker4, Oscar L. Lopez5, and Weiying Dai1

1Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 2Department of Radiation Oncology, Washington University, St Louis, MO, United States, 3Center of Neuroscience, University of Pittsburgh, PA, United States, 4Department of Psychology, University of Pittsburgh, PA, United States, 5Department of Psychiatry and Neurology, University of Pittsburgh, PA, United States

Biomarkers for Alzheimer’s disease (AD) are crucial for early diagnosis and treatment monitoring once therapies become available. In this study, the spin-lattice relaxation time in the rotating frame with (T1sat) and without (T1nosat) off-resonance saturation was measured at 1.5 T in the cardiovascular health study cognition study cohort. Cross-sectional and longitudinal studies of the normalized difference (ΔT1RF) between T1sat and T1nosat revealed regions of statistical significance in the brain that are associated with dementia pathogenesis. ΔT1RF changes in the thalamus were consistent for the cross-sectional and longitudinal studies, indicating that ΔT1RF could be a promising imaging biomarker for AD.

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