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Abstract #2359

Hippocampal atrophy is correlated to cerebrospinal fluid levels of ceruloplasmin, neuroinflammation and total tau in Alzheimer’s disease

Azhaar Ahmad Ashraf1 and Dr Po-Wah So1

1Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

The aim of the study was to characterise the relationship between cerebrospinal fluid (CSF) iron regulatory proteins (ferritin, ceruloplasmin), neuroinflammation and MRI-derived hippocampal volume in healthy controls, mild cognitive impairment and Alzheimer’s disease subjects. Ceruloplasmin positively correlated with neuroinflammation and ferritin in MCI and AD while in the latter group, it was negatively correlated with hippocampal volume. Ferritin positively correlated with neuroinflammation in HC and AD but also with tau levels in MCI. Iron dyshomeostasis, neuroinflammation and tau metabolism may increase hippocampal atrophy and aggravate AD pathogenesis.

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