Brain imaging research has elucidated the structural and functional changes at the clinical stages of AD and MCI, however, the characteristics of resting-state functional connectivity of SCI are largely unstudied. Hippocampus is among the first regions targeted by AD pathology. In this study, we employed resting state fMRI to study the connectivity between hippocampus and posterior cingulate cortex in SCI, MCI and AD groups. In the preliminary results, the connectivity between hippocampus and PCC in SCI was found stronger than control and other two neurodegenerative groups which may suggest that compensatory mechanisms providing preserved hippocampal pathway in SCI.
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