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Abstract #2361

Brain iron load, as measured by Quantitative Susceptibility Mapping, promotes beta-Amyloid associated functional brain change in elderly subjects but not in Super-Agers

Jiri MG van Bergen1, Xu Li2, Frances-Catherine Quevenco1, Sandra Leh1, Anton F Gietl1, Valerie Treyer1,3, Rafeal Meyer1, Alfred Buck3, Roger M Nitsch1, Peter CM van Zijl2, Christoph Hock1, and Paul G Unschuld1

1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland, 2F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, MD, United States, 3Department of Nuclear Medicine, University of Zurich, Switzerland

To investigate whether brain iron load has an impact on Aβ associated functional brain change, this study investigated a large sample of cognitively healthy adults including 44 Super-Agers (subjects over the age of 85 without cognitive impairments) using simultaneous assessment of Amyloid-PET for Aβ-plaque-density, QSM for estimation of iron load and resting-state-fMRI.

Our findings indicate that the combination of Aβ-plaque-density with other neurodegenerative change (iron), has an impact on brain functionality, reflected by significant changes of resting state functional connectivity. Additionally, Aβ-plaque-density had no significant effect on functional connectivity in Super-Agers.

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