The use of subtracted STIR images designed to null white and gray matter respectively is illustrated in formalin fixed brain samples at 11.7T. The images show the normal layers of the cerebral cortex with high contrast. The layers were less well seen, or not seen at all in Alzheimer’s Disease samples. Use of MT pulses with the STIR sequences produces high positive and negative contrast on difference images. The STIR subtraction technique made have general application, and be used with different forms of data acquisition. It may also be useful in other clinical situations for demonstrating changes due to small differences in T1 in the presence of long T1 fluids.
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