We evaluated the prevalence and its associated risk factors of motor cortex hypointensity on SWI in cognitive impaired patients. This retrospective study included 116 cognitively impaired patients (28 Alzheimer disease patients and 88 mild cognitive impaired patients). Among them, 83 patients showed positive motor cortex hypointensity on SWI and it was associated with age. Furthermore, the group with positive motor cortex hypointensity on SWI had less APOE4 allele carriers than negative group and this shows (+) APOE4 allele may act as an accelerating factor of cognitive decline even before iron accumulation starts to show changes in the motor cortex.
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