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Abstract #2368

Subcortical Nuclei Iron Deposition of Alzheimer's Patients on MRI-QSM: Maybe a Diagnostic Indicator

Lei Du1, Yijiang Zhu1, Tianbin Song2, Lizhi Xie3, and Guolin Ma1

1Department of Radiology, China-Japan Friendship Hospital, Beijing, People's Republic of China, 2Department of Nuclear Medicine, Xuanwu Hospital,Capital Medical University, Beijing, People's Republic of China, 3GE Healthcare, Beijing, People's Republic of China

Based on gradient echo (GRE) magnetic resonance phase data, quantitative susceptibility mapping (QSM) is a novel technique which allows the non-invasive assessment of magnetic tissue susceptibility distribution in mild alzheimer’s disease (AD). In this study ,we investigated the correlation between mini-mental state examination (MMSE) and bulk tissue magnetic susceptibility in subcortical nuclei of 14 mild AD subjects and 14 cognitively healthy controls scanned at 3T . A strong linear correlation between them was found in caudate nucleus and dentate nucleus. Hence, QSM can be used for early AD diagnosis and intervention.

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