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Abstract #2369

Hippocampal T1-weighted and FLAIR contrast is associated with CSF biomarkers in asymptomatic individuals with parental history of Alzheimer’s disease

Christine L Tardif1, Robert S C Amaral1, Gabriel A Devenyi1, Pedro Rosa-Neto2, Judes Poirier2, John Breitner2, M Mallar Chakravarty1, and The PREVENT-AD Research Group2

1Cerebral Imaging Centre, Douglas Mental Health Institute, Montreal, QC, Canada, 2Douglas Mental Health Institute, Montreal, QC, Canada

Cerebrospinal fluid (CSF) β-amyloid and phosphorylated-tau are consistently used as biomarkers related to the pathophysiology and clinical severity of individuals in the earliest phases of Alzheimer’s disease (AD). This study shows that T1-weighted and FLAIR signal intensity in the hippocampal subfields, normalized using the fimbria, are associated with ApoE4 status and CSF biomarkers. The FLAIR results suggest that presence of inflammation in the subiculum of ApoE4 carriers and in the CA1 and molecular layers of the hippocampus in subjects with low CSF β-amyloid burden as tau pathology increases.

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