Abstract #2370

Modulated the Physiological Response Delay to Prevent Overestimating the Disruption of Default Mode Network in Alzheimer’s Disease

Yi-Tien Li^1,2, Chun-Yuan Chang¹, Yi-Cheng Hsu¹, Jong-Ling Fuh³, and Fa-Hsuan Lin^1,4

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan, ³Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan, ⁴Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland

This study quantified the impact of physiological noise correction in characterizing the resting-state fMRI in Alzheimer’s disease (AD) patients with age- and gender-matched 17 healthy subjects and 15 AD patients. Using a seed-based correlation method with seeds at posterior cingular cortex and medial prefrontal cortex, we found that the difference in the functional connectivity between AD patients and healthy controls was significantly reduced when physiological noise was suppressed.

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