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Abstract #2371

Association between whole brain functional connectivity and cortical thickness throughout healthy aging

Bruno Hebling Vieira1 and Carlos Ernesto Garrido Salmon1

1InBrain Lab, Department of Physics, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

The aging process entails morphological and functional alterations in the human brain. Using magnetic resonance imaging data of 130 subjects aged between 18 and 81 years from a publicly available dataset we obtained whole brain cortical thickness estimates and resting state connectivity to study how healthy aging affects these. Additionally, we studied the relationship between cortical thickness and functional connectivity. A heterogeneous thinning profile was observed and also a dominance in increases in connectivity, with few decreases. Connectivity correlates with thickness with temporal and occipital seed ROIs. These results might help to understand how connectivity and thickness relate in neuropathologies.

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