Abstract #2372

Exaggeration of Tau Pathology by Amyloid-β production in PS2APPxTauP301L Transgenic Mouse Model of Alzheimer’s Disease

Vineela D Gandham¹, William J Meilandt², Kai H Barck¹, Maj Hedehus¹, Kimberly Malesky¹, Claire Le Pichon², Oded Foreman³, Gai Ayalon², Kimberly Scearce-Levie², and Richard AD Carano¹

¹Biomedical Imaging, Genentech, South San Francisco, CA, United States, ²Neuroscience, Genentech, South San Francisco, CA, United States, ³Pathology, Genentech, South San Francisco, CA, United States

The PS2APP, PS2APPxTau_P301L^Het, Tau_P301L^Homo, Tau_P301L^Het transgenic mouse models of AD were characterized using MRI, and various regional brain atrophies were detected using a completely automated analysis by SPM-8. Furthermore, through MRI (both ROI and voxel based morphometry) and histology we showed that the presence of PS2APP mutation in PS2APPxTau_P301L^Het triple transgenic mouse model exaggerates the Tau pathology. The presented results will enable MRI as a great tool to non-invasively assess the disease progression over time in preclinical therapeutic studies targeting Aβ and Tau pathology.

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