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Abstract #2372

Exaggeration of Tau Pathology by Amyloid-β production in PS2APPxTauP301L Transgenic Mouse Model of Alzheimer’s Disease

Vineela D Gandham1, William J Meilandt2, Kai H Barck1, Maj Hedehus1, Kimberly Malesky1, Claire Le Pichon2, Oded Foreman3, Gai Ayalon2, Kimberly Scearce-Levie2, and Richard AD Carano1

1Biomedical Imaging, Genentech, South San Francisco, CA, United States, 2Neuroscience, Genentech, South San Francisco, CA, United States, 3Pathology, Genentech, South San Francisco, CA, United States

The PS2APP, PS2APPxTauP301LHet, TauP301LHomo, TauP301LHet transgenic mouse models of AD were characterized using MRI, and various regional brain atrophies were detected using a completely automated analysis by SPM-8. Furthermore, through MRI (both ROI and voxel based morphometry) and histology we showed that the presence of PS2APP mutation in PS2APPxTauP301LHet triple transgenic mouse model exaggerates the Tau pathology. The presented results will enable MRI as a great tool to non-invasively assess the disease progression over time in preclinical therapeutic studies targeting Aβ and Tau pathology.

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