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Abstract #2379

Magnetic resonance spectroscopy demonstrates decreased glutamate in the anterior cingulate cortex in individuals with spinal cord injury

Carina Graf1,2, Erin L. MacMillan3, John K. Kramer2,4, and Cornelia Laule1,2,5

1Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 3Faculty of Medicine (Division of Neurology), University of British Columbia, Vancouver, BC, Canada, 4Faculty of Education (School of Kinesiology), University of British Columbia, Vancouver, BC, Canada, 5Department of Pathology & Laboratory Medicine, University of British Columbia

We investigated metabolites in the anterior cingulate cortex using magnetic resonance spectroscopy in individuals with spinal cord injury (SCI). Short-TE PRESS at 3T provided reliable fits for glutamate (Glu), N-Acetyl-aspartate (NAA), total creatine (tCr), myo-Inositol and total choline. SCI patients had 11.3 % less Glu. Given the role of Glu in synaptic transmission between neurons and also between neurons and oligodendrocytes, reduced Glu in SCI may reflect decreased synaptic density and activity due to a loss of sensory input in the anterior cingulate cortex. Further research investigating the effect of sensory input loss on metabolite concentrations in SCI is warranted.

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