Abstract #2380

Neurodegeneration and its interaction with motor impairment in sub-acute SCI revealed by quantitative MRI

Maryam Seif¹, Patrick Grabher¹, Alan Thompson², Armin Curt¹, and Patrick Freund^1,2,3,4

¹Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, ²Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ³Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, ⁴Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Spinal cord injury (SCI) leads to immediate sensorimotor and autonomic dysfunction and SCI patients generally show little clinical recovery within the first year after injury. Early structural changes at the spinal and brain level and their interactions with recovery rate are not well understood. The aim of our study was to reveal trauma-induced neurodegeneration and its interaction to impairment within early stage after injury employing quantitative neuroimaging technique. Our finding showed that significant atrophy and microstructural changes initiated in neural sensorimotor system within already early stage after SCI and quantitative neuroimaging methods hold potential to disclosing these neurodegeneration mechanisms.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.