The current study investigated the CEST sensitivity and specificity for simultaneous glucose (glucoCEST) and glutamate (gluCEST) detection on a phantom and a rodent brain injury. Using a median saturation power (2μT) and short saturation duration (2s), the MTRasym at 1.2, 2.1 and 2.9ppm could detect the glucose content, while the MTRasym at 3ppm could measure the glutamate in vivo. The glucoCEST results were compared in parallel to the 18F-FDG PET detecting the tissue uptake of glucose, while the gluCEST data were shown comparable to 18F-DPA PET radio-ligands binding to translocator protein (TSPO) for imaging microglial activation in the injured brain.
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