Abstract #2396

Imaging of thalamic calcium deposits due to sports-related concussion using Quantitative Susceptibility Mapping (QSM)

Ferdinand Schweser^1,2, Deepa P Ramasamy¹, Jesper Hagemeier¹, Barry Willer³, Nicola Bertolino¹, Dhaval Shah¹, David J Poulsen⁴, John Leddy⁵, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁵Department of Orthopaedics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

This work explored the hypothesis that the activation of N-methyl-D-aspartate (NMDA)-receptors in the thalamus results in persistent calcium deposits after a sports-related concussion that can be visualized clinically with Quantitative Susceptibility Mapping at 3 Tesla. The study involved 22 retired professional contact-sports athletes and 45 controls. We found a significantly higher incidence of thalamic micro-calcifications in contact-sports athletes compared to controls, in particular in ice hockey players.

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