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Abstract #2402

In-vivo 3D T1rho mapping of the whole Brain: Multi-component Analysis

Rajiv G Menon1, Azadeh Sharafi1, and Ravinder R Regatte1

1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, United States

In this study, we demonstrate the in vivo feasibility of multicomponent 3D-T1rho relaxation mapping of whole brain using 3T MRI in five healthy subjects. Our preliminary results suggest that the bi-exponential model better represents the relaxation behavior in white matter and has potential to differentiate between different water compartments associated with myelin bound water (short component) and intra-extracellular water (long component).

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