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Abstract #2404

Distributed rCBF changes caused by high frequency rTMS on lateral prefrontal cortex

Jun Xie1, Wei Peng1, Jian Zhang1, Da Chang1, and Ze Wang1

1Hangzhou Normal University, Hangzhou, People's Republic of China

The repetitive application of transcranial magnetic stimulation (rTMS) on left dorsolateral prefrontal cortex (DLPFC) have been consistently shown to be beneficial for treating various neuropsychiatrical or neuropsychological disorders, however its neural mechanisms still remain unclear. In this study, we measured the effects of high-frequency left DLPFC rTMS using cerebral blood flow (CBF). The results showed the rTMS induced CBF redistribution in the default mode network, including increased rCBF in temporal cortex which was correlated with increased behavior performance, but reduced rCBF in precuneus and cerebellum.

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