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Abstract #2410

Harmonization for fractional anisotropy measurement at 3T in healthy subjects

Miaomiao Wang1, Xianjun Li1,2, Chao Jin1, Congcong Liu1, Jianxin Guo1, Hui Hao1, and Jian Yang1

1Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People's Republic of China, 2Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University

In current clinical practice, the absence of standard protocol of diffusion tensor imaging (DTI) challenges the consistency of DTI data, and thus affects the accuracy of data group analysis. This study aims to assess the inconsistency of DTI-derived fractional anisotropy (FA) based on the different clinical protocols and further make them into harmonization. Results suggest the effects of slice thickness and b-value of FA are anatomy dependent, which is more stable in white matter with packed and orientation consistent fibers. Besides, a developed polynomial fitting model was used to make FA harmonization among different DTI protocols.

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