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Abstract #2411

Automatic registration of MRI and transcranial ultrasound for the analysis of neurological disorders

Yiming Xiao1,2, Dante De Nigris3, Ian J. Gerard4, Yuhan Ma4, Donatella Tampieri5, D. Louis Collins4, and Hassan Rivaz1,2

1PERFORM Centre, Concordia University, Montreal, QC, Canada, 2Department of Electrical and Computer Engineering, Concordia University, Montreal, QC, Canada, 3NeuroRx Research, Montreal, QC, Canada, 4Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 5Department of Diagnostic and Interventional Neuroradiology, Montreal Neurological Hospital, Montreal, QC, Canada

Transcranial ultrasound (TCUS) can be used to diagnose and monitor a range of neurological conditions, such as Parkinson’s disease. However, reliable quantitative examination and multi-modal image analysis that involves TCUS require TCUS-MRI registration to guide the interpretation and measurement of the TCUS. We demonstrate that accurate rigid registration can be achieved through aligning gradient orientations of the 3D TCUS and an associated pseudo-TCUS constructed from the T1w MRI.

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