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Abstract #2415

Bias in Aqueductal Cerebrospinal Fluid Flow Quantification Obtained using 2D PC-MRI

Sudarshan Ragunathan1,2 and James G Pipe1

1Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Biological Health and Systems Engineering, Arizona State University, Tempe, AZ, United States

This focus of this work was to determine the extent of RF saturation induced bias in cerebrospinal fluid flow quantification using 2D PCMRI. The velocity distribution within a flow region inherently biases the average estimate per voxel towards faster spins in that voxel. This effect was studied through variations in flip angle. The results indicated that higher flip angles would introduce more bias in the flow estimates, which could be a possible reason for the lack of consensus concerning the use of PCMRI in determining patient responsiveness to surgical interventions in NPH studies.

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