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Abstract #2419

Dynamic ADC Change during Cardiac Cycle in Human Brain in Sleep State

Ryoko Yamamori1, Tosiaki Miyati1, Naoki Ohno1, Yuki Hiramatsu1, Toshiharu Kurita2, Seika Miki1, Akiko Sekiya1, Yuri Hoshina3, and Toshifumi Gabata4

1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, Kawazawa, Japan, 2East Medic Corporation, Kanazawa, Ishikawa, Japan, Japan, 3Department of Inspection, Japanese Red Cross Kanazawa, Japan, 4Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan

The glymphatic system is a waste clearance pathway in brain. During sleep, the increase in the interstitial influx results in faster waste removal. Apparent diffusion coefficient (ADC) in brain significantly changed during the cardiac cycle, and this change (ΔADC) shows the degree of fluctuation in water molecules. Therefore, we analyzed fluctuation of water molecules in the brain of healthy subjects in awake and sleep states. Maximum ADC and ΔADC of the white matter increased in sleep state. Fluctuation analysis facilitates the noninvasive evaluation of the dynamic state of water movement in the brain in sleep state as a glymphatic MRI.

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