Abstract #2420

The Nulling Signal Produced by Inversion Recovery for Gray Matter is Related to Neuronal Density in the Thalamic Subnuclei: A 7T MRI Study

Nambeom Kim¹, Young-Don Son^1,2, Kyung-Jin Lee^1,2, Yeong-Bae Lee^1,3, and Chang-Ki Kang^1,4

¹Neuroscience Research Institute, Gachon university, Incheon, Korea, Republic of, ²Department of Biomedical Engineering, Gachon University, ³Department of Neurology, Gachon University Gil Medical Center, Gachon University, ⁴Department of Radiological Sciences, Gachon University

The thalamus acts as a gateway to higher brain centers that are involved in cognition, sleep, arousal, as well as sensory and motor information ^1–5. Additionally, changes in the thalamic subnuclei (TS) have been implicated in a number of neuropsychiatric disorders. In a postmortem study, the neuronal number as well as the total volume of the thalamus were significantly decreased in schizophrenic subjects or elevated in major depression subjects, especially in the medial dorsal nucleus ^6,7. As a result, the ability to estimate neuronal density in the thalamic subnuclei (TS) using in-vivo imaging is highly desired.

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