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Abstract #2426

Evaluating White Matter Changes in Amyotrophic Lateral Sclerosis from T1-weighted MRI using 3-D Texture Analysis

Abdullah Ishaque1, Yee-Hong Yang2, and Sanjay Kalra3

1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada, 2Department of Computing Science, University of Alberta, 3Division of Neurology, University of Alberta

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease of the motor system with substantial disease burden in white matter. Clinical MRI studies are used only to exclude diagnoses of symptom-mimicking neurological disorders. We propose that texture analysis performed on structural MRI can provide a surrogate marker for subtle white matter changes that are observed in ALS. This study shows significant correlations between texture features from T1-weighted imaging and diffusion measures such as fractional anisotropy and mean diffusivity. These texture features also demonstrated significant differences between ALS and controls and can potentially be used clinically for diagnosis and disease monitoring.

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