Abstract #2427

Impact of the topology of brain microbleeds on the structural brain network

Xiaopei Xu¹, Henry KF Mak^1,2, Kui-Kai Lau³, Pak Lun Lam⁴, and Edward S Hui^1,2

¹Department of Diagnostic Radiology, The University of Hong Kong, HKSAR, People's Republic of China, ²The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, HKSAR, People's Republic of China, ³Department of Medicine, The University of Hong Kong, HKSAR, People's Republic of China, ⁴Li Ka Shing Faculty of Medicine, The University of Hong Kong, HKSAR, People's Republic of China

We aim to investigate the effect of the topology of brain microbleeds (BMBs), lobar (n = 32) versus deep/infratentorial (n = 31), on structural brain network in patients with TIA or first-time stroke. Our results demonstrated that the efficiency of the local and global networks of both BMB cohorts were lower compared to controls (n = 31), and that only the load of the patients with lobar BMBs was strongly associated with decrease in the efficiency of local and global networks independent of vascular risk factors. These findings suggested that lobar and deep BMBs likely have distinct pathophysiological underpinnings.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.